Systems biology is largely tributary to genomics and other “omic” disciplines that generate vast amounts of structural data. “Omics”, however, lack a theoretical framework that would allow using these data sets as such (rather than just tiny bits that are extracted by advanced data-mining techniques) to build explanatory models that help understand physiological processes. Systems biology provides such a framework by adding a dynamic dimension to merely structural “omics”. It makes use of bottom-up and top-down models. The former are based (...) on data about systems components, the latter on systems-level data. We trace back both modeling strategies (which are often used to delineate two branches of the field) to the modeling of metabolic and signaling pathways in the bottom-up case, and to biological cybernetics and systems theory in the top-down case. We then argue that three roots of systems biology must be discerned to account adequately for the structure of the field: pathway modeling, biological cybernetics, and “omics”. We regard systems biology as merging modeling strategies (supplemented by new mathematical procedures) from data-poor fields with data supply from a field that is quite deficient in explanatory modeling. After characterizing the structure of the field, we address some epistemological and ontological issues regarding concepts on which the top-down approach relies and that seem to us to require clarification. This includes the consequences of identifying modules in large networks without relying on functional considerations, the question of the “holism” of systems biology, and the epistemic value of the “systeome” project that aspires to become the cutting edge of the field. (shrink)

The philosophy of Descartes is the classical example of a Philosophy as a System intending to found itself on an absolute point of view or to come from an absolute starting point. However, the Cogito being regarded by Descartes as the first principle, actually is neither a first nor a definite nor a sufficient principle, leading to further conclusions. Above all Descartes himself, thus becoming the first Anti-Cartesian, compromises this so-called first and greatest evidence by stating that God ist the (...) most evident principle, from which everything has to be deduced. The myth of clarity conceals the true, uncertain and inquiring Descartes. (shrink)

It is therefore most appropriate that Yoga and Indian philosophy be given equal attention both in the context of academic research and in the framework of ...

Ich erörtere die beiden folgenden Thesen:1. Der technisch-wissenschaftliche Fortschrift ist als Ganzes nicht zu steuern, und zwar gerade dann nicht, wenn er eine Zivilisation wie die unsere westliche total durchdringt. Die Nichtplanbarkett des Gesamtprozesses ist seine wichtigste Rahmenbedingung. Man hat aber einen ideologischen Begriff von Rationalität, wenn man den Entwicklungszug des 'Fortschrifts' deshalb als 'irrational' bezeichnen würde.2. Die Akzeptierung des Umstands, daß der technisch-wissenschaftliche Fortschritt nicht planbar ist, ist einer der augenfälligsten Preise, die wir für die Erhaltung der liberalen Demokratie (...) bei uns zu zahlen haben. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Guilt History:Benjamin's Sketch "Capitalism as Religion"Werner Hamacher (bio)Translated by Kirk Wetters (bio)History as Exchange EconomySince history cannot be conceived as a chain of events produced by mechanical causation, it must be thought of as a connection between occurrences that meets at least two conditions: first that it admit indeterminacy and thus freedom, and second that it nonetheless be demonstrable in determinate occurrences and in the distinct form of (...) their coherence. Relations can thus be called historical and can be recognized as historical only if they are determined by neither necessity nor chance, and if their causality is of a different order than the mechanical. The temporal structure of history can therefore be characterized on the one hand by the distinct connection of its elements—and on the other hand by the dissolution of all connections that do not assist these elements in achieving their independence.A temporal nexus that clearly does not satisfy these conflicting requirements has been characterized in one of the oldest texts of occidental philosophy as the time of guilt. According to the sentence of Anaximander (from about 500 BC), handed down by Simplicius in his commentary (530 AD) on Aristotle's Physics, the origin and end of all things is subordinated to the law of necessity (katà tó kreòn). "They must pay penance and be judged for their injustice, according to the order of time (katà tèn tou chrónou táxin)"—so the fragment reads in the translation offered by Nietzsche in his treatise "Philosophy in the Tragic Age of the Greeks." According to Anaximander, the sequence of time orders the rise and fall of all things and orders them in accordance with the law of guilt and punishment so that becoming (génesis) is a guilt (adikía) that must be expiated in perishing. Time and more precisely its táxis, the positing of time, is thought in Anaximander's sentence as an order of guilt and retribution, debt and payback. It is a time of economy in the sense that it is the time of law—and precisely a law that is valid for all beings, a táxis, a decree, an ordinance and an ordering—in which the unavoidable incurring of guilt is atoned in an equivalent penance that is just as unavoidable. The strict coherence of guilt and penance is ascertained by the principle of their equivalence. Time is therefore conceived here as a double process of coming into being and perishing, [End Page 81] a process that occurs in such a way that the genesis is erased in its passing away—so that time is thus erased by time itself.In Anaximander's sentence, however, time is not only the double-process of coming into being and passing away, it is—as a táxis—the common and constantly enduring medium of the exchange of the contrary but equivalent motions of coming into being and perishing. It is the time of the quid pro quo of everything that is generated and passes away within time. Its measure is a justice that represents itself as a táxis and thereby as the positing and the law of all becoming and vanishing, the law of physis and its demise as an onto-economic law. This taxiological order of time places every realm of the natural and human world under a law of substitution without exception; this also allows ethical, juridical, and economic concepts to substitute for one another within this order. The ethical dimension of justice, thus circumscribed by the order of time, is reduced to the juridical dimension of the decree, and both now define themselves according to the calculus of "an exchange economy in an eternally unchanging household of nature."1 It can only, however, be a matter of an ethics of time to the extent that this ethics, already juridified and economized, is subordinated to the schema of exchange, trade, and the equivalence of guilt and retribution. The time of history, ethical time, is thus interpreted in Anaximander's sentence as a normative time of inculpation and expiation. Whatever enters this táxis of time is thereby already guilty and can... (shrink)